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Adipex-P is a brand-name version of generic phentermine medicine useful in treating obesity along with a proper diet and exercise routine. It is an oral medication for short-term use for up to a few weeks. Adipex-P is a central nervous system stimulant and an appetite suppressant. Phentermine, the active ingredient of Adipex pills, got approval for medical use in 1959 in the United States.

It is available for brand and generic formulations. Adipex-P is one of the most prescribed medications of its kind, with more than 2 million prescriptions every year.

Uses of Adipex-P

Adipex-P is helpful for a short period to promote weight loss when calorie reduction and exercise are not sufficient, as well as with exercise and a low-calorie diet. The FDA approves Adipex-P for up to 12 weeks of use, while most weight loss occurs within the first two weeks. However, weight loss continues through the sixth month and at a reduced rate through the ninth month. Adipex-P is not for use in patients with a history of drug abuse, allergic reactions to sympathomimetic amine drugs, hyperthyroidism, cardiovascular disease, pregnancy, or taking an MAO inhibitor.

Mechanism of Action

Adipex-P works similarly to its parent compound amphetamine, as they both are the agonists of TAAR1. The TAAR1 activation in monoamine neurons facilitates the efflux of the neurochemicals. At clinical doses, Adipex-P acts as a norepinephrine-releasing agent in neurons, and to a reduced extent, it also releases serotonin and dopamine into the synapses. Adipex-P also triggers the release of monoamines from VMAT2, as it is a common effect of substituted amphetamines.

The primary mechanism of action of Adipex-P in treating obesity is the reduction of hunger perception. It is a cognitive process mediated through several nuclei within the hypothalamus, particularly the lateral hypothalamic nucleus, ventromedial nucleus, and arcuate nucleus. The medicine releases epinephrine and norepinephrine outside the brain, causing fat cells to break down the stored fat.

Adverse Effects

Patients report rare cases of pulmonary hypertension and cardiac diseases with the use of Adipex-P. Tolerance to the medication usually occurs; however, there are negligible risks of dependence and addiction. People using the medication may have impairment while driving or operating machinery.

Consumption of alcohol with Adipex-P produces adverse effects. Talk to a doctor about all the precautions associated with this medication before you buy Adipex-P online.

Currently, no evidence or studies demonstrate the safety of the medication for pregnant women.

Other adverse effects of Adipex-P include:

  • Cardiovascular effects like tachycardia, palpitations, precordial pain, high blood pressure, angina, myocardial infarction, cardiac arrest, or cardiac failure can occur.
  • Central nervous system effects such as overstimulation, nervousness, restlessness, tremor, insomnia, headache, dizziness, hallucinations, and depression take place.
  • Gastrointestinal effects, including dry mouth, nausea, vomiting, cramps, diarrhea, unpleasant taste, and constipation, develops.
  • Other adverse effects such as rash, impotence, trouble urinating, facial swelling, and changes in libido may also occur.


Adipex-P contains phentermine that interacts with several drugs to decrease their effects:

  • Clonidine
  • Methyldopa
  • Guanethidine

Medications used to treat hypothyroidism increase the effects of phentermine. It is advisable not to buy Adipex-P online and use it with any medicine that interacts with it.